Volume 27 of "Progress in Drug Research" contains 5 articles, a subject index for this volume, an alphabetic subject 4ldex for volumes 1-27, and an author and subject index for altthe volumes which have so far been published. The contributions of volume 27 are particularly concerned with fungal disease, with benzimidazole anthelmintics and with the chemistry and pharmacology of quinuclidines, azoles, and nitroimida zoles. The authors have tried, not only to summarize the current status of particular fields of drug research, but also to provide leads for future research activity. The articles of this volume will be of special value to those actively engaged in drug research, and to those who wish to keep abrest of the latest developments influencing modem therapy. In addi tion, it is believed that the 27 volumes of "Progress in Drug Research" now available represent a useful reference work of encyclopedic charac ter. The editor would like to take the occasion of the publication of this volume to express his gratitude both to the authors and to the readers. The authors have willingly1undertaken'the great labor of writing signifi cant topical contributions, hnd many readers have helped the editor with criticism and advise. With these thanks, the editor would like also to express his gratitude to the publisher, Birkhauser Verlag Basel, particu larly to Messrs. Th. Birkhauser and C. Einsele, and their associates for the excellent cooperation.